110174-72-6

Upstream product

• 110174-70-4 5,5-Dimethyl-2-<1-(1-piperidinio)-cyclopropyl>-1-oxo-2-cyclohexen-3-olat 
• 75-36-5 acetyl chloride 

Downstream Products

• 132292-34-3 C₁₈H₁₉NO₂ 
• 132292-40-1 3-(2-chloroethyl)-6,7-dihydro-6,6-dimethyl-2-phenylamino-benzofuran-4(5H)-one 
• 132292-39-8 N-tert-butyl-1-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)cyclopropanecarboxamide 
• 120229-81-4 2-<1-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)cyclopropyl>-N-methyl-N,2-diphenylacetamid 
• 120229-80-3 N,N-Diethyl-2-<1-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)cyclopropyl>-2-phenylacetamid 
• 120262-50-2 5,6,7,8-Tetrahydro-7,7-dimethyl-3-phenylspiro-2,5-dion 
• 120229-73-4 N,N-Diethyl-2-<1-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)cyclopropyl>propionamid 
• 120229-82-5 2-<1-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)cyclopropyl>essigsaeure-ethylestercetamid 
• 120229-74-5 4-Ethyliden-5,6,7,8-tetrahydro-7,7-dimethyl-2-phenyl-4H-chromen-5-on 
• 120229-67-6 2-(Dimethylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-3-phenylspiro-<4H-chromen-4,1'-cyclopropan>-5-on 
• 120229-71-2 5,6,7,8-Tetrahydro-7,7-dimethyl-2-phenylspirospiro<4H-chromen-4,1'-cyclopropan>-5-on 
• 110174-75-9 6,7-dihydro-6,6-dimethyl-3-<<1-(3-hydroxy-5,5-dimethyl-1-oxocyclohex-2-en-2-yl)cycloprop-1-yl>methyl>benzofuran-4(5H)-one 
• 110174-74-8 2,3,6,7-tetrahydro-6,6-dimethylbenzofuran-4(5H)-one-3-spiro-2'-<7',8'-dihydro-7',7'-dimethylchroman-5'(6'H)-one>-4'-spiro-1''cyclopropane 
• 110174-78-2 9-<1-(3-hydroxy-5,5-dimethyl-1-oxocyclohex-2-en-2-yl)cycloprop-1-yl>-3,4,6,7,8,9-hexahydro-3,3-dimethyldibenzofuran-1(2H)-one 

Relevant academic research and scientific papers

Cycloaddition Reactions of 2-Cyclopropylidene-1,3-diones with Electron-Rich Alkynes

Cyclopropylidenedimedone 3, an unstable and highly reactive intermediate, is trapped in a Hetero Diels-Alder reaction by the addition of ynamines 7a-c, f, ynether 7d, or phenylacetylene (7e).Heterolysis of the resulting cycloadducts 8a-d, f leads to carboxylic acid derivatives 9a-d, f.The latter may be regarded as the result of a twofold nucleophilic substitution at a cyclopropane system according to their synthesis by the sequence 17-> 5-> 8-> 9.An opening of the cyclopropane ring takes place during hydrolysis of cycloadduct 8e producing 11.Analogously, 2-cyclopropylidene-1,3-diones 13A-13C can be generated by aminocyclopropylation of CH acids 18A-18C and subsequent deamination induced by an acylation reaction.Trapping of 13A - 13C by ethoxyacetylene (7d) or ethyl vinyl ether (4) provides the analogous cycloadducts 14A, B and 15C. - Key Words: 2-Cyclopropylidene-1,3-diones / Hetero Diels-Alder reaction / Cyclopropane derivatives

An O --> N Acyl Transfer. An Important Activation Step for a Formal Nucleophilic Substitution in a Cyclopropane Derivative

Acylated (piperidinocyclopropyl)dimedone 8 proved to be a suitable starting material for smooth generation of a highly reactive cyclopropylidenedimedone species (9).The latter can be trapped in a cycloaddition with enol ethers 14 leading to 15 o