N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide

Base Information

• Chemical Name: N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide
• CAS No.: 847549-18-2
• Molecular Formula: C₁₇H₁₅Br₂N₃O₅S
• Molecular Weight: 533.197

Synonyms:N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide

Chemical Property of N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide

There total 3 articles about N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-[2-(6-bromo-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide (847549-17-1) → N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide (847549-18-2)

Guidance literature:

With N-Bromosuccinimide; water; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃; for 2h;

DOI:10.1021/ol047532v

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide (847549-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N; DMAP / CH₂Cl₂ / 6 h / 20 °C

2: 83 percent / N-bromosuccinimide; H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 20 °C

With dmap; N-Bromosuccinimide; water; triethylamine; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;

DOI:10.1021/ol047532v

Reference yield:

N-Methyl-6-bromotryptamine (209169-05-1) → N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide (847549-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N; DMAP / CH₂Cl₂ / 6 h / 20 °C

2: 83 percent / N-bromosuccinimide; H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 20 °C

With dmap; N-Bromosuccinimide; water; triethylamine; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;

DOI:10.1021/ol047532v

upstream raw materials:

N-[2-(6-bromo-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide

4-Nitrobenzenesulfonyl chloride

N-Methyl-6-bromotryptamine

Downstream raw materials:

N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-2-methoxy-3H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

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