N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine

Base Information

• Chemical Name: N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine
• CAS No.: 954387-00-9
• Molecular Formula: C₁₇H₂₅BrN₂O₂
• Molecular Weight: 369.302
• Mol file: 954387-00-9.mol

Synonyms:N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine

Chemical Property of N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine

There total 4 articles about N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.3%

3-Quinuclidinone (3731-38-2) + 4-Bromo-2-(2,2-dimethoxyethyl)aniline (954386-99-3) → N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine (954387-00-9)

Guidance literature:

3-Quinuclidinone; 4-Bromo-2-(2,2-dimethoxyethyl)aniline; With acetic acid; sodium sulfate; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; at 20 ℃; for 44h;

With water; sodium hydrogencarbonate;

Reference yield:

C10H11BrN2O2 (105205-48-9) → N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine (954387-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: chloro-trimethyl-silane / Reflux

2: sodium dithionite; sodium hydrogencarbonate / ethanol / Reflux

3: sodium tris(acetoxy)borohydride; sodium sulfate / acetic acid / 20 °C

With chloro-trimethyl-silane; sodium dithionite; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; sodium sulfate; In ethanol; acetic acid;

DOI:10.1016/j.bmcl.2011.07.022

Reference yield:

4-Bromo-2-(2,2-dimethoxyethyl)-1-nitrobenzene (954386-98-2) → N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine (954387-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium dithionite; sodium hydrogencarbonate / ethanol / Reflux

2: sodium tris(acetoxy)borohydride; sodium sulfate / acetic acid / 20 °C

With sodium dithionite; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; sodium sulfate; In ethanol; acetic acid;

DOI:10.1016/j.bmcl.2011.07.022

upstream raw materials:

3-Quinuclidinone

4-Bromo-2-(2,2-dimethoxyethyl)aniline

C₁₀H₁₁BrN₂O₂

4-Bromo-2-(2,2-dimethoxyethyl)-1-nitrobenzene