954386-98-2

Upstream product

• 52414-98-9 5-bromo-2-nitrotoluene 
• 67-56-1 methanol 
• 105205-48-9 C₁₀H₁₁BrN₂O₂ 
• 105205-48-9 [(E)-2-(5-bromo-2-nitro-phenyl)-vinyl]-dimethyl-amine 

Downstream Products

• 954386-99-3 4-Bromo-2-(2,2-dimethoxyethyl)aniline 
• 954387-00-9 N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine 

Relevant academic research and scientific papers

1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

A series of 1,5-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase. A variety of flexible and restricted basic amine side chain substitutions was explored at the 1-position of the indole r

1,5 And 3,6- substituted indole compounds having NOS inhibitory activity

The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, or chronic pain.