7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide

Base Information

Chemical Name:7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide
CAS No.:82874-36-0
Molecular Formula:C₁₆H₁₃Cl₂N₂O*I
Molecular Weight:447.103
Hs Code.:

Synonyms:7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide

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Technology Process of 7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide

There total 7 articles about 7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.8%

: 2894-67-9
delorazepam

: 74-88-4
methyl iodide

: 82874-36-0
7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide

Guidance literature:: In acetonitrile; at 60 ℃; for 4h;
DOI:10.1248/cpb.30.1141

Reference yield:

: 2894-71-5,49853-64-7
7-chloro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione

: 82874-36-0
7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 50percent NaH / 1.) mineral oil, DMF, r.t., 20 min; 2.) mineral oil, DMF, r.t., 1 h

2: 40 percent / 10 percent NaOH / H₂O / 4 h / 50 °C / further reagent: HCl; further solvent: aq. DMSO; further temperatures and reaction times

3: 29.3 percent / 5percent HCl / methanol; H₂O / 2.5 h / -20 °C

4: 92.8 percent / acetonitrile / 4 h / 60 °C

With hydrogenchloride; sodium hydroxide; sodium hydride; In methanol; water; acetonitrile;
DOI:10.1248/cpb.30.1141

Reference yield:

: 57616-47-4
7-chloro-5-(2-chlorophenyl)-2-(2-dimethylaminoethylthio)-3H-1,4-benzodiazepine

: 82874-36-0
7-chloro-5-(2-chlorophenyl)-2,3-dihydro-4-methyl-2-oxo-1H-1,4-benzodiazepinium iodide

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / 10 percent NaOH / H₂O / 4 h / 50 °C / further reagent: HCl; further solvent: aq. DMSO; further temperatures and reaction times

2: 29.3 percent / 5percent HCl / methanol; H₂O / 2.5 h / -20 °C

3: 92.8 percent / acetonitrile / 4 h / 60 °C

With hydrogenchloride; sodium hydroxide; In methanol; water; acetonitrile;
DOI:10.1248/cpb.30.1141