(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol

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Chemical Name:(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol
CAS No.:1262967-62-3
Molecular Formula:C₂₈H₂₁F₁₂NO₂
Molecular Weight:631.461
Hs Code.:

Synonyms:(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol

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Technology Process of (3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol

There total 1 articles about (3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: 114676-48-1
(2S,4R)-1-benzyl-4-hydroxyproline methyl ester

: 1262967-62-3
(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol

Guidance literature:: 3,6-bis(trifluoromethyl)bromobenzene; With magnesium; In tetrahydrofuran;

(2S,4R)-1-benzyl-4-hydroxyproline methyl ester; In tetrahydrofuran; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2010.10.020

Reference yield: 95.0%

: 2067-33-6
5-bromopentanoic acid

: 1262967-62-3
(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol

: 1262967-64-5
{(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1.66667h; Reflux;
DOI:10.1016/j.tetasy.2010.10.020