{(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate

Base Information

Chemical Name:{(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate
CAS No.:1262967-64-5
Molecular Formula:C₃₃H₂₈BrF₁₂NO₃
Molecular Weight:794.475
Hs Code.:

Synonyms:{(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate

Suppliers and Price of {(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate

There total 1 articles about {(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2067-33-6
5-bromopentanoic acid

: 1262967-62-3
(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol

: 1262967-64-5
{(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1.66667h; Reflux;
DOI:10.1016/j.tetasy.2010.10.020

Reference yield: 55.0%

: 616-47-7
1-methyl-1H-imidazole

: 1262967-64-5
{(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate

: 1-{5-[(3R,5S)-1-benzyl-5-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)pyrrolidin-3-yloxy]-5-oxopentyl}-3-methyl-1H-imidazol-3-ium hexafluorophosphate

Guidance literature:: 1-methyl-1H-imidazole; {(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate; at 100 ℃; for 0.166667h;

With potassium hexafluorophosphate; In methanol; water;
DOI:10.1016/j.tetasy.2010.10.020