Technology Process of toluene-4-sulfonic acid 2-(2-ethynyl-5,6,4'-trimethoxy-biphenyl-3-yl)-ethyl ester
There total 10 articles about toluene-4-sulfonic acid 2-(2-ethynyl-5,6,4'-trimethoxy-biphenyl-3-yl)-ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
DOI:10.1021/jo026337w
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 50 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -10 - 20 °C
2: 90 percent / aq. HCl / 0.33 h / Heating
3: 100 percent / diisobutylaluminum hydride / CH2Cl2; toluene / -78 °C
4: 75 percent / imidazole / dimethylformamide / 0.33 h / 20 °C
5: 96 percent / pyridinium dichromate; 4 Angstroem molecular sieves / CH2Cl2 / 20 °C
6: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / -78 - 20 °C
7: 340 mg / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C
8: 93 percent / Et3N / CH2Cl2 / 20 °C
With
1H-imidazole; hydrogenchloride; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; triethylamine; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo026337w
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 50 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -10 - 20 °C
2: 90 percent / aq. HCl / 0.33 h / Heating
3: 100 percent / diisobutylaluminum hydride / CH2Cl2; toluene / -78 °C
4: 75 percent / imidazole / dimethylformamide / 0.33 h / 20 °C
5: 96 percent / pyridinium dichromate; 4 Angstroem molecular sieves / CH2Cl2 / 20 °C
6: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / -78 - 20 °C
7: 340 mg / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C
8: 93 percent / Et3N / CH2Cl2 / 20 °C
With
1H-imidazole; hydrogenchloride; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; triethylamine; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo026337w
