6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide

Base Information

Chemical Name:6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide
CAS No.:1159600-12-0
Molecular Formula:C₁₉H₁₅F₄N₃O₃
Molecular Weight:409.34
Hs Code.:

Synonyms:6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide

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Chemical Property of 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide

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Technology Process of 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide

There total 6 articles about 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 753-90-2
trifluoroethylamine

: 1159600-11-9
6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

: 1159600-12-0
6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide

Guidance literature:: trifluoroethylamine; With trimethylaluminum; In 1,4-dioxane; toluene; at 20 ℃; for 1h;

6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester; In 1,4-dioxane; toluene; at 85 - 95 ℃; for 2h;

Reference yield:

: 1159251-38-3
[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol

: 1159600-12-0
6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

2.1: trimethylaluminum / toluene; 1,4-dioxane / 1 h / 20 °C

2.2: 2 h / 85 - 95 °C

With trimethylaluminum; sodium hydride; In tetrahydrofuran; 1,4-dioxane; toluene; mineral oil;

Reference yield:

: 58606-42-1
N-hydroxy-3-fluoro-benzenecarboximidoyl chloride

: 1159600-12-0
6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / diethyl ether / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

4.1: trimethylaluminum / toluene; 1,4-dioxane / 1 h / 20 °C

4.2: 2 h / 85 - 95 °C

With lithium aluminium tetrahydride; trimethylaluminum; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; toluene; mineral oil;