tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

Base Information

Chemical Name:tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate
CAS No.:1403258-30-9
Molecular Formula:C₄₀H₅₅N₅O₅
Molecular Weight:685.907
Hs Code.:

tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

Synonyms:tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

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Chemical Property of tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

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Technology Process of tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

There total 9 articles about tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1403258-30-9
tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 5 h / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

4.1: acetic acid / methanol / 8 h / 20 °C

4.2: 0 °C

5.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

5.2: 0 - 20 °C

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iron; sodium carbonate; ammonium chloride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,1-dichloroethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 7.1: Suzuki Coupling;

Reference yield:

: 79669-49-1
5-bromo-2-methylbenzoic acid

: 1403258-30-9
tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; sulfuric acid / acetone / 2.25 h / -5 - 0 °C / Cooling with acetone-ice

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

4.1: acetic acid / methanol / 8 h / 20 °C

4.2: 0 °C

5.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

5.2: 0 - 20 °C

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

With sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; nitric acid; iron; sodium carbonate; ammonium chloride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,1-dichloroethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 7.1: Suzuki Coupling;

Reference yield:

: 1000342-11-9
2-methyl-3-amino-5-bromobenzoic acid methyl ester

: 1403258-30-9
tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 8 h / 20 °C

1.2: 0 °C

2.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

2.2: 0 - 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,1-dichloroethane; water; dimethyl sulfoxide; 4.1: Suzuki Coupling;