5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

Base Information

Chemical Name:5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
CAS No.:1403256-00-7
Molecular Formula:C₃₇H₄₉N₅O₄
Molecular Weight:627.827
Hs Code.:

5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

Synonyms:5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

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Chemical Property of 5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

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Technology Process of 5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

There total 11 articles about 5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.04%

: 1403255-99-1
5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

: 64-19-7,77671-22-8
acetic acid

: 1403256-00-7
5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1403256-00-7
5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 5 h / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

4.1: acetic acid / methanol / 8 h / 20 °C

4.2: 0 °C

5.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

5.2: 0 - 20 °C

6.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.2: pH 6

6.3: pH 4

7.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

7.2: 20 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

9.1: trifluoroacetic acid / dichloromethane / 2 h / 100 °C

10.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; water; iron; sodium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,1-dichloroethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 8.1: Suzuki Coupling;

Reference yield:

: 79669-49-1
5-bromo-2-methylbenzoic acid

: 1403256-00-7
5-(((1R,4R)-4-acetamidocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: nitric acid; sulfuric acid / acetone / 2.25 h / -5 - 0 °C / Cooling with acetone-ice

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

4.1: acetic acid / methanol / 8 h / 20 °C

4.2: 0 °C

5.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

5.2: 0 - 20 °C

6.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.2: pH 6

6.3: pH 4

7.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

7.2: 20 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

9.1: trifluoroacetic acid / dichloromethane / 2 h / 100 °C

10.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With sulfuric acid; water; nitric acid; iron; sodium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,1-dichloroethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 8.1: Suzuki Coupling;