5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

Base Information

Chemical Name:5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide
CAS No.:1403255-99-1
Molecular Formula:C₃₅H₄₇N₅O₃
Molecular Weight:585.79
Hs Code.:

5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

Synonyms:5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

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Chemical Property of 5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

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Technology Process of 5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

There total 11 articles about 5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1403258-30-9
tert-butyl ((1R,4R)-4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-carbamoyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-(ethyl)-amino)-cyclohexyl)-carbamate

: 1403255-99-1
5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 100 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1403255-99-1
5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 5 h / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

4.1: acetic acid / methanol / 8 h / 20 °C

4.2: 0 °C

5.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

5.2: 0 - 20 °C

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 100 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iron; sodium carbonate; ammonium chloride; acetic acid; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,1-dichloroethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 7.1: Suzuki Coupling;

Reference yield:

: 79669-49-1
5-bromo-2-methylbenzoic acid

: 1403255-99-1
5-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid; sulfuric acid / acetone / 2.25 h / -5 - 0 °C / Cooling with acetone-ice

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

4.1: acetic acid / methanol / 8 h / 20 °C

4.2: 0 °C

5.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

5.2: 0 - 20 °C

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 100 °C

With sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; nitric acid; iron; sodium carbonate; ammonium chloride; acetic acid; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,1-dichloroethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 7.1: Suzuki Coupling;