tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate

Base Information

Chemical Name:tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate
CAS No.:1380331-34-9
Molecular Formula:C₁₇H₁₇FN₄O₂
Molecular Weight:328.346
Hs Code.:

Synonyms:tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate

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Chemical Property of tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate

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Technology Process of tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate

There total 8 articles about tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.9%

: 26386-88-9
diphenyl phosphoryl azide

: 1380331-33-8
6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid

: 1380331-34-9
tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate

Guidance literature:: With triethylamine; In tert-butyl alcohol; at 25 ℃; for 18h; Reflux;

Reference yield: 39.9%

: 1380331-33-8
6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1380331-34-9
tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; for 18h; Reflux;

Reference yield:

: 885588-12-5
2-bromo-5-fluoropyridine-4-carboxylic acid

: 1380331-34-9
tert-butyl 6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzene; methanol / 1.5 h / Cooling

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5.5 h / 100 °C / Inert atmosphere

3.1: hydrogenchloride / diethyl ether / 20 h / 25 °C

3.2: 0 °C

4.1: dichloromethane / 2 h / 20 °C / Cooling with ice

5.1: pyridine / 20 h / 100 °C

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 25 °C

7.1: triethylamine / tert-butyl alcohol / 18 h / 25 °C / Reflux

With pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; tert-butyl alcohol; benzene;