2-Bromo-5-fluoroisonicotinic acid

Base Information

• Chemical Name: 2-Bromo-5-fluoroisonicotinic acid
• CAS No.: 885588-12-5
• Molecular Formula: C6H3 Br F N O2
• Molecular Weight: 219.998
• Hs Code.: 2933399090
• Mol file: 885588-12-5.mol

Synonyms:2-Bromo-5-fluoroisonicotinicacid; 2-Bromo-5-fluoropyridine-4-carboxylic acid

Chemical Property of 2-Bromo-5-fluoroisonicotinic acid

Chemical Property:

• Vapor Pressure: 2.4E-07mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 406.7ºC at 760 mmHg
• PKA: 2.05±0.10(Predicted)
• Flash Point: 199.8ºC
• PSA: 50.19000
• Density: 1.903g/cm3
• LogP: 1.68140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-fluoroisonicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-fluoroisonicotinic acid

There total 1 articles about 2-Bromo-5-fluoroisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromo-5-fluoropyridine (41404-58-4) + carbon dioxide (124-38-9,18923-20-1) → 2-bromo-5-fluoropyridine-4-carboxylic acid (885588-12-5)

Guidance literature:

2-bromo-5-fluoropyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -70 - -60 ℃; for 1.5h;

carbon dioxide; In tetrahydrofuran; hexane; at -70 - 20 ℃;

Reference yield: 93.0%

2-bromo-5-fluoropyridine-4-carboxylic acid (885588-12-5) + ethanol (64-17-5) → ethyl 2-bromo-5-fluoropyridine-4-carboxylate (1072206-72-4)

Guidance literature:

With thionyl chloride; at 0 ℃; Reflux;

DOI:10.1016/j.bmcl.2021.128109

Reference yield: 92.6%

methanol (67-56-1) + 2-bromo-5-fluoropyridine-4-carboxylic acid (885588-12-5) → methyl 2-bromo-5-fluoro-pyridine-4-carboxylate (885588-14-7)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

upstream raw materials:

2-bromo-5-fluoropyridine

carbon dioxide

Downstream raw materials:

methyl 2-bromo-5-fluoro-pyridine-4-carboxylate

4-(azetidine-1-carbonyl)-N-(6-fluoro-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1-methyl-1H-pyrazole-5-carboxamide

methyl 2-((tert-butoxycarbonyl)amino)-5-fluoropyridine-4-carboxylate

methyl 2-amino-5-fluoroisonicotinate

Refernces