(S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1228552-80-4
Molecular Formula:C₃₈H₄₄N₈O₄
Molecular Weight:676.819
Hs Code.:

(S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

There total 10 articles about (S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261071-78-6
(S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

: 1228552-80-4
(S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With ammonium acetate; In 4-methyl-1,2,3-trifluorobenzene; at 120 ℃; for 16h; Product distribution / selectivity; Sealed tube;

Reference yield:

: 771583-12-1
2-(aminomethyl)-4-bromoaniline

: 1228552-80-4
(S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: trichlorophosphate / 2 h / Reflux

3.1: chloranil / toluene / 4 h / Reflux

4.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: bromine; hydrogen bromide / acetic acid / 1 h / 0 - 20 °C

5.2: 0 °C

6.1: triethylamine; phosphonic acid diethyl ester / tetrahydrofuran / 4 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 20 °C

8.1: ammonium acetate / 4-methyl-1,2,3-trifluorobenzene / 16 h / 120 °C / Sealed tube

With ammonium acetate; hydrogen bromide; bromine; chloranil; triethylamine; N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile; 4-methyl-1,2,3-trifluorobenzene;

Reference yield:

: 39263-32-6
2-amino-5-bromobenzonitrile

: 1228552-80-4
(S)-2-[5-(4-{6-[2-((S)-1-carboxylic acid tert-butyl ester-pyrrolidin-2-yl)-3H-imidazol-4-yl]quinazolin-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: borane-THF / tetrahydrofuran / 72 h / 0 - 20 °C

1.2: 0 °C

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: trichlorophosphate / 2 h / Reflux

4.1: chloranil / toluene / 4 h / Reflux

5.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

5.2: 1 h / 20 °C

6.1: bromine; hydrogen bromide / acetic acid / 1 h / 0 - 20 °C

6.2: 0 °C

7.1: triethylamine; phosphonic acid diethyl ester / tetrahydrofuran / 4 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 20 °C

9.1: ammonium acetate / 4-methyl-1,2,3-trifluorobenzene / 16 h / 120 °C / Sealed tube

With borane-THF; ammonium acetate; hydrogen bromide; bromine; chloranil; triethylamine; N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile; 4-methyl-1,2,3-trifluorobenzene;