(S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

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Chemical Name:(S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester
CAS No.:1261071-78-6
Molecular Formula:C₃₈H₄₄N₄O₁₀
Molecular Weight:716.788
Hs Code.:

(S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

Synonyms:(S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

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Chemical Property of (S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

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Technology Process of (S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

There total 9 articles about (S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1261071-77-5
2-bromo-1-{2-[4-(2-bromoacetyl)phenyl]quinazolin-6-yl}ethanone

: 1261071-78-6
(S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1.5h; Product distribution / selectivity;

Reference yield:

: 771583-12-1
2-(aminomethyl)-4-bromoaniline

: 1261071-78-6
(S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: trichlorophosphate / 2 h / Reflux

3.1: chloranil / toluene / 4 h / Reflux

4.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: bromine; hydrogen bromide / acetic acid / 1 h / 0 - 20 °C

5.2: 0 °C

6.1: triethylamine; phosphonic acid diethyl ester / tetrahydrofuran / 4 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 20 °C

With hydrogen bromide; bromine; chloranil; triethylamine; N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 39263-32-6
2-amino-5-bromobenzonitrile

: 1261071-78-6
(S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(4-{6-[2-((S)-1-carboxylic acid tert-butyl-ester-pyrrolidine-2-carbonyloxy)acetyl]quinazolin-2-yl}phenyl)-2-oxoethyl] ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: borane-THF / tetrahydrofuran / 72 h / 0 - 20 °C

1.2: 0 °C

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: trichlorophosphate / 2 h / Reflux

4.1: chloranil / toluene / 4 h / Reflux

5.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

5.2: 1 h / 20 °C

6.1: bromine; hydrogen bromide / acetic acid / 1 h / 0 - 20 °C

6.2: 0 °C

7.1: triethylamine; phosphonic acid diethyl ester / tetrahydrofuran / 4 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 20 °C

With borane-THF; hydrogen bromide; bromine; chloranil; triethylamine; N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile;