4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline

Base Information

Chemical Name:4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline
CAS No.:1373944-38-7
Molecular Formula:C₂₀H₂₃ClFN₅O₂
Molecular Weight:419.886
Hs Code.:

Synonyms:4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline

Suppliers and Price of 4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline

There total 5 articles about 4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 4-(3′-chloro-4′-fluoroanilino)-6-(3-bromopropoxy)-7-methoxyquinazoline

: 107-15-3,85404-18-8
ethylenediamine

: 1373944-38-7
4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline

Guidance literature:: In acetonitrile; at -20.16 ℃; for 2.5h;
DOI:10.1016/j.ejmech.2012.07.036

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1373944-38-7
4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 3 h / Reflux

2: sodium methylate / methanol / 0.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

4: acetonitrile / 2.5 h / Reflux

With sodium methylate; potassium carbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1039/c5dt01430a

Reference yield:

: 184475-71-6
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

: 1373944-38-7
4-(3-chloro-4-fluoroanilino)-6-(N-(2-aminoethyl)aminopropoxy)-7-methoxyquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 4.5 h / Reflux

2: acetonitrile / 2.5 h / -20.16 °C

With potassium carbonate; In acetone; acetonitrile;
DOI:10.1016/j.ejmech.2012.07.036