(-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline

Base Information

Chemical Name:(-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline
CAS No.:898530-56-8
Molecular Formula:C₂₈H₃₃BrN₂O₆SSi
Molecular Weight:633.635
Hs Code.:

Synonyms:(-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline

Suppliers and Price of (-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline

There total 7 articles about (-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 898530-55-7
(+)-[(2S)-3-(o-nitrobenzenesulfonylamino)-1-(4-benzyloxy-2,6-dibromophenyl)propan-2-yloxy](tert-butyl)dimethylsilane

: 898530-56-8
(-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline

Guidance literature:: With copper(l) iodide; cesium acetate; In dimethyl sulfoxide; at 60 ℃; for 24h;
DOI:10.1021/ja0619455

Reference yield:

: 898530-54-6
(-)-(2S)-1-(4-benzyloxy-2,6-dibromophenyl)-3-chloropropan-2-ol

: 898530-56-8
(-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 12.8 g / NaN₃ / dimethylformamide / 9 h / 90 °C

2: 15.0 g / imidazole; DMAP / dimethylformamide / 6 h / 50 °C

3: tetrahydrofuran / 0.5 h / 20 °C

4: water / tetrahydrofuran / 2 h / 20 °C

5: 16.4 g / sodium bicarbonate / tetrahydrofuran; H₂O / 42 h / 20 °C

6: 83 percent / copper iodide; cesium acetate / dimethylsulfoxide / 24 h / 60 °C

With 1H-imidazole; dmap; copper(l) iodide; sodium azide; water; cesium acetate; sodium hydrogencarbonate; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 3: Staudinger reaction;
DOI:10.1021/ja0619455

Reference yield:

: 3-(4-benzyloxy-2,6-dibromo-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-propylamine

: 898530-56-8
(-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 16.4 g / sodium bicarbonate / tetrahydrofuran; H₂O / 42 h / 20 °C

2: 83 percent / copper iodide; cesium acetate / dimethylsulfoxide / 24 h / 60 °C

With copper(l) iodide; cesium acetate; sodium hydrogencarbonate; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/ja0619455