Technology Process of 2-(4-((4-Cyanobenzamido) methyl)phenoxy)acetic acid
There total 5 articles about 2-(4-((4-Cyanobenzamido) methyl)phenoxy)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / acetone / 12 h / Reflux
2: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C
4: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
5: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C
With
lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU;
10% palladium on charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C
3: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
4: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C
With
lithium hydroxide monohydrate; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU;
10% palladium on charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
