Technology Process of 4-cyano-N-(4-(2-(2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-5(4H)-yl)-2-oxoethoxy)benzyl)benzamide
There total 7 articles about 4-cyano-N-(4-(2-(2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-5(4H)-yl)-2-oxoethoxy)benzyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(4-((4-Cyanobenzamido) methyl)phenoxy)acetic acid;
With
benzotriazol-1-ol;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.166667h;
(meso)-3,4-isopropylidenedioxy-2,5-pyrrolidine hydrotosylate;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 12 h / Reflux
2.1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C
4.1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C
6.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C
6.2: 20 °C
With
lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; HATU;
10% palladium on charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C
3.1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C
5.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C
5.2: 20 °C
With
lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; HATU;
10% palladium on charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
