7-methyl-2,4-diphenyl-quinazoline

Base Information

• Chemical Name: 7-methyl-2,4-diphenyl-quinazoline
• CAS No.: 16151-75-0
• Molecular Formula: C₂₁H₁₆N₂
• Molecular Weight: 296.371
• Mol file: 16151-75-0.mol

Synonyms:7-methyl-2,4-diphenyl-quinazoline

Chemical Property of 7-methyl-2,4-diphenyl-quinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-methyl-2,4-diphenyl-quinazoline

There total 15 articles about 7-methyl-2,4-diphenyl-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-methyl-2-cyanoaniline (26830-96-6) + benzaldehyde (100-52-7) + phenylboronic acid (98-80-6) → 7-methyl-2,4-diphenyl-quinazoline (16151-75-0)

Guidance literature:

With potassium fluoride; 5,5'-dimethyl-2,2'-bipyridine; bis(acetylacetonato)palladium(II); trifluorormethanesulfonic acid; In N,N-dimethyl-formamide; at 80 ℃; for 48h; Sealed tube; Schlenk technique;

DOI:10.1021/acs.orglett.8b01070

Reference yield: 81.0%

7-methyl-2-phenylquinazolin-4-yl 4-methylbenzenesulfonate (1315336-93-6) + phenylmagnesium bromide (100-58-3) → 7-methyl-2,4-diphenyl-quinazoline (16151-75-0)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 0.75h; Inert atmosphere;

DOI:10.1002/jhet.2513

Reference yield: 75.0%

2-(m-tolyl)-2,3-dihydrophthalazine-1,4-dione (103724-31-8) + diphenyl acetylene (501-65-5) → 7-methyl-2,4-diphenyl-quinazoline (16151-75-0)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 1,3-bis-(diphenylphosphino)propane; copper(II) acetate monohydrate; potassium carbonate; In tert-Amyl alcohol; at 90 ℃; for 8h;

DOI:10.1021/acs.orglett.8b00643

upstream raw materials:

N-(3-methylphenyl)benzimidoyl chloride

N-benzylbenzamide

N-(chloro(phenyl)methylene)(phenyl)methanamine

N-benzyl-N′-(m-tolyl)benzimidamide