(R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

Base Information

Chemical Name:(R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene
CAS No.:1452782-73-8
Molecular Formula:C₃₁H₃₄F₂N₄O₃S
Molecular Weight:580.699
Hs Code.:

(R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

Synonyms:(R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

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Chemical Property of (R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

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Technology Process of (R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

There total 5 articles about (R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1452782-94-3
(R)-6-(3-bromobenzenesulfonyl)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

: 136725-53-6,169750-17-8,136725-55-8
(3R)-3-fluoropyrrolidine hydrochloride

: 1452782-73-8
(R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1452782-95-4
(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-4a-hydroxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

: 1452782-73-8
(R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; water / 23 h / 40 °C

2: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; water;

Reference yield:

: 1452782-96-5
(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester

: 1452782-73-8
(R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 10 °C / Inert atmosphere

2: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; water / 23 h / 40 °C

3: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; dichloromethane; water; toluene;