(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester

Base Information

Chemical Name:(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester
CAS No.:1452782-96-5
Molecular Formula:C₂₄H₂₁BrFN₃O₄S
Molecular Weight:546.417
Hs Code.:

Synonyms:(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester

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Chemical Property of (R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester

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Technology Process of (R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester

There total 1 articles about (R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864972-21-4
6-tert-butyl 4a-methyl (4aR)-1-(4-fluorophenyl)-4a,5,7,8-tetrahydro-1H-pyrazolo[3,4-g]isoquinoline-4a,6(4H)-dicarboxylate

: 2905-24-0
3-Bromobenzenesulfonyl chloride

: 1452782-96-5
(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester

Guidance literature:: 6-tert-butyl 4a-methyl (4aR)-1-(4-fluorophenyl)-4a,5,7,8-tetrahydro-1H-pyrazolo[3,4-g]isoquinoline-4a,6(4H)-dicarboxylate; With hydrogenchloride; In 1,4-dioxane; water; for 1.25h;

3-Bromobenzenesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1452782-96-5
(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester

: 1452782-95-4
(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-4a-hydroxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 - 10 ℃; Inert atmosphere;

Reference yield:

: 1452782-96-5
(R)-6-(3-bromobenzenesulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester

: 1452782-73-8
(R)-4a-((cyclopropylmethoxy)methyl)-1-(4-fluorophenyl)-6-[3-((R)-3-fluoropyrrolidin-1-yl)benzenesulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 10 °C / Inert atmosphere

2: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; water / 23 h / 40 °C

3: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; dichloromethane; water; toluene;