(1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide

Base Information

Chemical Name:(1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide
CAS No.:1459729-22-6
Molecular Formula:C₁₃H₁₄N₂O
Molecular Weight:214.267
Hs Code.:

Synonyms:(1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide

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Chemical Property of (1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide

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Technology Process of (1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide

There total 3 articles about (1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.1%

: 1225330-50-6
(1R,2S)-1-(E)-N-phenylmethyleneamino-2-vinylcyclopropanecarboxylic acid ethyl ester

: 1459729-22-6
(1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide

Guidance literature:: With sodium methylate; formamide; In tetrahydrofuran; methanol; toluene; at 50 ℃; for 4h;
DOI:10.1039/c3ob41394b

Reference yield:

: 821-06-7
(E)-1,4-dibromobutene

: 169962-99-6
Benzylidene glycine amide

: C₁₃H₁₄N₂O

: 1459729-22-6
(1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide

Guidance literature:: Benzylidene glycine amide; With N-[2,5-bis(trifluoromethyl)benzyl]cinchonidinium bromide; In toluene; at 5 ℃; for 0.25h;

(E)-1,4-dibromobutene; With sodium hydroxide; In water; toluene; at 10 ℃; Overall yield = 82 %Chromat.; enantioselective reaction;
DOI:10.1039/c3ob41394b

Reference yield:

: 133038-44-5
[(benzylidene)amino]acetic acid ethyl ester

: 1459729-22-6
(1R,2S)-1-((E)-benzylideneamino)-2-vinylcyclopropane carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-[2,5-bis(trifluoromethyl)benzyl]cinchonidinium bromide / toluene / 0.25 h / 5 °C

1.2: 10 °C

2.1: formamide; sodium methylate / toluene; tetrahydrofuran; methanol / 4 h / 50 °C

With N-[2,5-bis(trifluoromethyl)benzyl]cinchonidinium bromide; sodium methylate; formamide; In tetrahydrofuran; methanol; toluene;
DOI:10.1039/c3ob41394b