methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate

Base Information

Chemical Name:methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate
CAS No.:1228591-21-6
Molecular Formula:C₂₅H₂₁N₃O₆
Molecular Weight:459.458
Hs Code.:

Synonyms:methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate

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Chemical Property of methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate

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Technology Process of methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate

There total 1 articles about methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1092395-04-4
3-(1-cyano-1-methylethyl)-N-(3-hydroxyphenyl)benzamide

: 2965-22-2
methyl 2-fluoro-5-nitro-benzoate

: 1228591-21-6
methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 92.0%

: 1228591-21-6
methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate

: 1228591-22-7
methyl 5-amino-2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]benzoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; at 20 ℃; for 14h; under 760.051 Torr;

Reference yield:

: 1228591-21-6
methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate

: 1228591-20-5
methyl 6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazole-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol; 1-methyl-pyrrolidin-2-one / 14 h / 20 °C / 760.05 Torr

2.1: acetic acid / 0.17 h / 20 °C

2.2: 3 h / 20 °C

3.1: pyridine / 2 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1021/jm400778d