methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate

Base Information

Chemical Name:methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate
CAS No.:1228591-23-8
Molecular Formula:C₂₆H₂₂N₄O₄S
Molecular Weight:486.551
Hs Code.:

Synonyms:methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate

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Chemical Property of methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate

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Technology Process of methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate

There total 5 articles about methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1228591-22-7
methyl 5-amino-2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]benzoate

: 333-20-0
potassium thioacyanate

: 1228591-23-8
methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate

Guidance literature:: potassium thioacyanate; With acetic acid; at 20 ℃; for 0.166667h;

methyl 5-amino-2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]benzoate; In acetic acid; at 20 ℃; for 0.166667h;

With bromine; In acetic acid; at 20 ℃;

Reference yield: 90.0%

: 1228591-22-7
methyl 5-amino-2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]benzoate

: 333-20-0
potassium thioacyanate

: 1228591-23-8
methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate

: 1448850-80-3
C₂₆H₂₂N₄O₄S

Guidance literature:: methyl 5-amino-2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]benzoate; potassium thioacyanate; With acetic acid; at 20 ℃; for 0.166667h;

With bromine; at 20 ℃; for 3h; regioselective reaction;
DOI:10.1021/jm400778d

Reference yield:

: 1228591-21-6
methyl 2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-5-nitrobenzoate

: 1228591-23-8
methyl 2-amino-6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-1,3-benzothiazole-7-carboxylate

: 1448850-80-3
C₂₆H₂₂N₄O₄S

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol; 1-methyl-pyrrolidin-2-one / 14 h / 20 °C / 760.05 Torr

2.1: acetic acid / 0.17 h / 20 °C

2.2: 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1021/jm400778d