N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Base Information

• Chemical Name: N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide
• CAS No.: 1361330-28-0
• Molecular Formula: C₂₆H₂₇ClN₄O₅S
• Molecular Weight: 543.043
• Mol file: 1361330-28-0.mol

Synonyms:N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Chemical Property of N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

There total 7 articles about N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H35ClN4O7S → N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide (1361330-28-0)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃;

Reference yield:

2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate (1361330-48-4) + 3-chlorophenylsulfonyl chloride (2888-06-4) → N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide (1361330-28-0)

Guidance literature:

2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate; 3-chlorophenylsulfonyl chloride; With pyridine; In dichloromethane; at 20 ℃; for 0.55h;

With methanol; potassium carbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1021/jm301572h

Reference yield:

2-fluoro-6-methoxybenzonitrile (94088-46-7) → N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide (1361330-28-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h

4.2: 0.5 h / 20 °C

5.1: pyridine / dichloromethane / 0.5 h / 20 °C

6.1: potassium carbonate; methanol / 20 °C

With pyridine; methanol; lithium aluminium tetrahydride; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

upstream raw materials:

2-fluoro-6-methoxybenzonitrile

4-(methyloxy)-1H-indazol-3-amine

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile

1,1-dimethylethyl (2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino} ethyl)carbamate