2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate

Base Information

• Chemical Name: 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate
• CAS No.: 1361330-48-4
• Molecular Formula: C₂₂H₂₆N₄O₄
• Molecular Weight: 410.473
• Mol file: 1361330-48-4.mol

Synonyms:2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate

Chemical Property of 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate

There total 4 articles about 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-amine (1361330-32-6) + 2-acetoxy-2-methylpropanoyl chloride (40635-66-3) → 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate (1361330-48-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile (1240518-02-8) → 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate (1361330-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

2: triethylamine / dichloromethane / 18 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

2-fluoro-6-methoxybenzonitrile (94088-46-7) → 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate (1361330-48-4)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

4: triethylamine / dichloromethane / 18 h / 20 °C

With lithium aluminium tetrahydride; hydrazine hydrate; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; butan-1-ol;

upstream raw materials:

2-fluoro-6-methoxybenzonitrile

1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-amine

2-acetoxy-2-methylpropanoyl chloride

4-(methyloxy)-1H-indazol-3-amine

Downstream raw materials:

N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

N-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

N-[(3-{[3-{[(2,3-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide