Disalicylimide

Base Information

Chemical Name:Disalicylimide
CAS No.:1972-71-0
Molecular Formula:C14H11NO4
Molecular Weight:257.246
Hs Code.:
UNII:QN42R68E24
DSSTox Substance ID:DTXSID30877409
Nikkaji Number:J1.605.605G
Wikidata:Q82859201
ChEMBL ID:CHEMBL580072
Mol file:1972-71-0.mol

Synonyms:disalicyloyl-amine;N-Salicyloylsalicylamid;JS-2-90;Disalicylamide;2-hydroxy-N-(2-hydroxybenzoyl)benzamide;

Suppliers and Price of Disalicylimide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Disalicylimide
2.5g
$ 1070.00

Medical Isotopes, Inc.
DeferasiroxDiacylImpurity
100 mg
$ 550.00

Total 46 raw suppliers

Chemical Property of Disalicylimide

Chemical Property:

Melting Point:203-204 °C
Boiling Point:503.8±50.0 °C(Predicted)
PKA:7.48±0.30(Predicted)
PSA：86.63000
Density:1.382±0.06 g/cm3(Predicted)
LogP:2.05890
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Very Slightly, Sonicated), Pyridine (Slightly)
XLogP3:3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:257.06880783
Heavy Atom Count:19
Complexity:312

Purity/Quality:

98%,99%, ^*data from raw suppliers

Disalicylimide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)NC(=O)C2=CC=CC=C2O)O
Uses Disalicylimide is an impurity of Deferasirox (D228650), an orally active tridentate iron chelator.

Technology Process of Disalicylimide

There total 21 articles about Disalicylimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 65-45-2
salicylamide

: 69-72-7,25496-36-0,8052-31-1
salicylic acid

: 1972-71-0
2-hydroxy-N-(2-hydroxybenzoyl)benzamide

Guidance literature:: salicylic acid; With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 50 ℃; for 2h;

salicylamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; toluene; acetonitrile; at 5 ℃; for 24h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; toluene; acetonitrile; at 20 ℃; for 2h;

Reference yield: 76.0%

: 1369525-64-3
2-(benzyloxy)-N-[(2-hydroxyphenyl)carbonyl]benzamide

: 1972-71-0
2-hydroxy-N-(2-hydroxybenzoyl)benzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h;
DOI:10.1021/jm2015183

Reference yield: 75.0%

: 1441-87-8
salicyloyl chloride

: 1972-71-0
2-hydroxy-N-(2-hydroxybenzoyl)benzamide

Guidance literature:: salicyloyl chloride; With 1,1,1,3,3,3-hexamethyl-disilazane; In toluene; at 0 - 10 ℃; for 1h; Inert atmosphere;

With ethanol; Reflux;