1,2-DIMETHOXY-4-FLUOROBENZENE

Base Information

• Chemical Name: 1,2-DIMETHOXY-4-FLUOROBENZENE
• CAS No.: 398-62-9
• Molecular Formula: C8H9FO2
• Molecular Weight: 156.157
• Hs Code.: 29093090
• Mol file: 398-62-9.mol

Synonyms:3,4-Dimethoxyfluorobenzene;4-Fluoro-1,2-dimethoxybenzene;4-Fluoroveratrole;

Chemical Property of 1,2-DIMETHOXY-4-FLUOROBENZENE

Chemical Property:

• Appearance/Colour: white to light yellow crystal
• Refractive Index: n20/D 1.51(lit.)
• Boiling Point: 180.559 °C at 760 mmHg
• Flash Point: 91.667 °C
• PSA: 18.46000
• Density: 1.102 g/cm³
• LogP: 1.84290
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Water Solubility.: Soluble in water 0.079 g/L 25°C.

Purity/Quality:

97% ^*data from raw suppliers

1,2-Dimethoxy-4-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Fluoro-1,2-dimethoxybenzene is a raw material used in organic synthesis.

Technology Process of 1,2-DIMETHOXY-4-FLUOROBENZENE

There total 19 articles about 1,2-DIMETHOXY-4-FLUOROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3,4-dimethoxyphenol (2033-89-8) + Cl(1-)*C27H36ClN2(1+)*Cs(1+)*F(1-) → 4-fluoroveratrole (398-62-9)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 23 - 140 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol5035518

Reference yield: 78.0%

3,4-dimethoxybenzenediazonium tetrafluoroborate → 4-fluoroveratrole (398-62-9)

Guidance literature:

With sodium fluoride; In toluene; for 6h; Heating;

Reference yield: 75.0%

C20H13F4O2S2(1+)*BF4(1-) → 4-fluoroveratrole (398-62-9)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; cesium fluoride; In acetone; at 30 ℃; for 20h; Inert atmosphere; Irradiation;

DOI:10.1038/s41557-019-0353-3

upstream raw materials:

methanol

3,4-dimethyl-fluorobenzene

3,4-dimethoxyaniline

4-Bromoveratrole

Downstream raw materials:

2-(chloromethyl)-4,5-dimethoxy-1-fluorobenzene

6-fluoro-2,3-dimethoxybenzaldehyde

6-fluoro-2,3-dimethoxybenzoic acid

4-bromo-5-fluorobenzene-1 ,2-diol