(E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid

Base Information

• Chemical Name: (E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid
• CAS No.: 144562-60-7
• Molecular Formula: C₂₄H₃₁NO₅
• Molecular Weight: 413.514
• Mol file: 144562-60-7.mol

Synonyms:(E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid

Chemical Property of (E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid

There total 8 articles about (E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate (144562-59-4) → (E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid (144562-60-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 1h; Heating;

DOI:10.1021/jm950725r

Reference yield:

2,5-dimethoxy-3,6-dimethylbenzaldehyde (104129-40-0) → (E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid (144562-60-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) m-CPBA, 2.) sodium methoxide / 1.) CH₂Cl₂, reflux, 30 min, 2.) methanol, RT, 30 min

2: 1.) TiCl₄ / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

3: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, RT, 3 h

4: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 50 deg C, overnight

5: 100 percent / NaOH / ethanol; H₂O / 1 h / Heating

With sodium hydroxide; sodium methylate; titanium tetrachloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In ethanol; water;

DOI:10.1021/jm950725r

Reference yield:

5-pyridin-3-yl-pentan-1-ol (84200-03-3) → (E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid (144562-60-7)

Guidance literature:

Multi-step reaction with 4 steps

1: mesyl chloride, Et₃N / CH₂Cl₂ / 1 h

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 60 deg C, 12 h

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 50 deg C, overnight

4: 100 percent / NaOH / ethanol; H₂O / 1 h / Heating

With sodium hydroxide; sodium hydride; methanesulfonyl chloride; triethylamine; In ethanol; dichloromethane; water;

DOI:10.1021/jm950725r

upstream raw materials:

ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate

2,5-dimethoxy-3,6-dimethylbenzaldehyde

5-pyridin-3-yl-pentan-1-ol

3-(5-Chloro-pentyl)-pyridine

Downstream raw materials:

(E)-3-(2-methoxy-3,6-dimethyl-1,4-benzoquinon-5-yl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid