ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate

Base Information

Chemical Name:ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate
CAS No.:144562-59-4
Molecular Formula:C₂₆H₃₅NO₅
Molecular Weight:441.568
Hs Code.:

Synonyms:ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate

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Chemical Property of ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate

Chemical Property:

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Technology Process of ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate

There total 7 articles about ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: n-hexane→ethyl acetate

: 92421-47-1
2,5-dimethyl-3,4,6-trimethoxybenzaldehyde

: 144563-18-8
ethyl 2-diethylphosphono-7-(3-pyridyl)heptanoate

: 144562-59-4
ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate

Guidance literature:: In ice-water; N,N-dimethyl-formamide;

Reference yield:

: 84200-03-3
5-pyridin-3-yl-pentan-1-ol

: 144562-59-4
ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: mesyl chloride, Et₃N / CH₂Cl₂ / 1 h

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 60 deg C, 12 h

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 50 deg C, overnight

With sodium hydride; methanesulfonyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm950725r

Reference yield:

: 104129-40-0
2,5-dimethoxy-3,6-dimethylbenzaldehyde

: 144562-59-4
ethyl (E)-3-(2,4,5-trimethoxy-3,6-dimethylphenyl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) m-CPBA, 2.) sodium methoxide / 1.) CH₂Cl₂, reflux, 30 min, 2.) methanol, RT, 30 min

2: 1.) TiCl₄ / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

3: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, RT, 3 h

4: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 50 deg C, overnight

With sodium methylate; titanium tetrachloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
DOI:10.1021/jm950725r