(R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid

Base Information

Chemical Name:(R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid
CAS No.:1329170-34-4
Molecular Formula:C₃₁H₄₇N₅O₇Si
Molecular Weight:629.829
Hs Code.:

(R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid

Synonyms:(R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid

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Chemical Property of (R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid

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Technology Process of (R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid

There total 4 articles about (R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 54594-06-8
D-allylglycine

: 1329167-29-4
tert-butyl N-[(1S)-1-(4-{2-bromo-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

: 1329170-34-4
(R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid

Guidance literature:: With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 90 ℃;
DOI:10.1016/j.bmcl.2020.126949

Reference yield:

: 1329167-30-7
tert-butyl N-[(1S)-1-(4-{2-amino-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

: 1329170-34-4
(R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid

Guidance literature:: tert-butyl N-[(1S)-1-(4-{2-amino-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate; With ethyl trifluoroacetaldehyde hemiacetal; In ethanol; at 120 ℃;

With allylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2020.126949

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1329170-34-4
(R)-2-(2-(2-((S)-1-(tert-butoxycarbonylamino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-5-(methoxycarbonylamino)phenylamino)pent-4-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-Methyldicyclohexylamine / tetrahydrofuran / 20 h / 0 - 20 °C

2: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 18 h / 90 °C / Inert atmosphere

With copper(l) iodide; N-Methyldicyclohexylamine; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;