(rac)-(1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepin-4-yl)-phenyl-methanol hydrochloride

Base Information

Chemical Name:(rac)-(1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepin-4-yl)-phenyl-methanol hydrochloride
CAS No.:1080026-88-5
Molecular Formula:C₂₀H₂₂ClNO*ClH
Molecular Weight:364.315
Hs Code.:

Synonyms:(rac)-(1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepin-4-yl)-phenyl-methanol hydrochloride

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Chemical Property of (rac)-(1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepin-4-yl)-phenyl-methanol hydrochloride

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Technology Process of (rac)-(1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepin-4-yl)-phenyl-methanol hydrochloride

There total 2 articles about (rac)-(1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepin-4-yl)-phenyl-methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepine-4-carbaldehyde hydrochloride

: 100-58-3
phenylmagnesium bromide

: 1080026-88-5
(rac)-(1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepin-4-yl)-phenyl-methanol hydrochloride

Guidance literature:: 1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepine-4-carbaldehyde hydrochloride; phenylmagnesium bromide; In tetrahydrofuran; diethyl ether; for 2h; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; for 0.75h;

Reference yield:

: 1208-76-0
1-benzyl-1,2,3,5,6,7-hexahydroazepine-4-one hydrochloride

: 1080026-88-5
(rac)-(1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepin-4-yl)-phenyl-methanol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 8 - 18 °C

1.2: 16 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 2 h / Heating / reflux

2.2: 0.75 h

With trichlorophosphate; In tetrahydrofuran; diethyl ether;