1208-76-0

Usage

Uses

Used in Pharmaceutical Industry:
1-BENZYL-4-OXOAZEPANE HCL is used as an intermediate in the synthesis of various pharmaceutical products for its ability to contribute to the development of new medications.
Used in Psychiatric Drug Development:
1-BENZYL-4-OXOAZEPANE HCL is used as a potential psychiatric drug for its effects on the central nervous system, indicating its utility in treating related disorders.
Used in Research and Development:
1-BENZYL-4-OXOAZEPANE HCL is used as a building block in the creation of novel molecules with potential therapeutic applications, driving innovation in medicinal chemistry.
Used in Organic Synthesis:
1-BENZYL-4-OXOAZEPANE HCL is used as an important intermediate in organic synthesis, facilitating the development of new chemical compounds and materials.

Upstream product

• 1164-14-3 ethyl 4-(N-benzyl-N-(2-ethoxycarbonylethyl))aminobutyrate 
• 23583-21-3 ethyl-3-benzylamino propionate 
• 23574-01-8 3-benzylamino-propionic acid methyl ester 
• 109386-71-2 methyl 4-(N-benzyl-N-(2-methoxycarbonylethyl))aminobutyrate 

Downstream Products

• 109162-29-0 1-benzyl-4-hydroxyhexahydro-1H-azepine 
• 49569-46-2 1-benzyl-5-bromohexahydroazepin-4-one hydrobromide 
• 344304-24-1 1-benzyl-5-chloro-2,3, 6,7-tetrahydro-1H-azepine-4-carbaldehyde 
• 324784-93-2 5-phenyl-2,3,4,7-tetrahydro-1H-azepine 
• 324784-95-4 4-phenyl-2,3,6,7-tetrahydro-1H-azepine 
• 1422424-43-8 C₁₈H₂₅NO₂ 
• 1422424-44-9 C₁₃H₁₇N 
• 1422424-50-7 C₁₈H₂₄F₃NO₃ 
• 1422424-51-8 C₁₃H₁₄F₃N 
• 1422424-52-9 C₁₃H₁₄F₃N 
• 1422424-56-3 C₁₇H₂₃ClFNO₃ 
• 1422424-57-4 C₁₂H₁₃ClFN 
• 1422424-58-5 C₁₂H₁₃ClFN 
• 1422424-62-1 C₁₃H₁₄F₃NO 

Relevant academic research and scientific papers

Method for the preparation of hexahydroazepinones and hexahydroazepinoles

This disclosure describes two technical procedures for the high-yield synthesis of heterocyclic seven-membered ring-systems by Dieckmann-condensation avoiding usual dilution techniques and long reaction times. Thus, it significantly increases the overall yields of the pharmaceutically active ingredients azelastine and flezelastine, whose synthesis, starting from these seven-membered heterocyclic rings, is reported elsewhere. Yields range from 80-89%, avoiding waste and increasing economics of the synthesis.

HETEROCYCLIC ETHERS DERIVED FROM 6,11-DIHYDRODIBENZOTHIEPIN-11-OLS AND 4,9-DIHYDROTHIENO-2-BENZOTHIEPIN-4-OL; A NEW SERIES OF POTENTIAL ANTIDEPRESSANTS AND ANTIHISTAMINE AGENTS

Reactions of 11-chloro-6,11-dihydrodibenzothiepin and methanesulfonates of 6,11-dihydrodibenzothiepin-11-ol (I), its 2-methyl derivative II and 4,9-dihydrothieno-2-benzothiepin-4-ol (III) with 1-methylpiperidin-4-ol, 1-methylperhydroazepin-4-ol (XIX), and tropine gave the ethers V-X.Their methanesulfonates were pharmacologically tested and showed antireserpine, anticataleptic, and antihistamine activities of various degree.The most active compounds were the ethers V and VI.