methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

Base Information

Chemical Name:methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate
CAS No.:916493-58-8
Molecular Formula:C₂₇H₂₄N₄O₃S
Molecular Weight:484.579
Hs Code.:

Synonyms:methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

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Chemical Property of methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

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Technology Process of methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

There total 2 articles about methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 916489-36-6
methyl 2-((6S,Z)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl)acetate

: 40138-16-7
2-formylbenzene boronic acid

: 916493-58-8
methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

Guidance literature:: With cesium fluoride; palladium diacetate; johnphos; In tetrahydrofuran; for 8h; Heating / reflux;

Reference yield:

: 202592-23-2
(S)-[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

: 916493-58-8
methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 5 h / 0 - 20 °C

2: cesium fluoride / palladium diacetate; johnphos / tetrahydrofuran / 8 h / Heating / reflux

With thionyl chloride; cesium fluoride; palladium diacetate; johnphos; In tetrahydrofuran;

Reference yield:

: 916493-58-8
methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate

: [(S)-4-(2'-cyanobiphenyl-4-yl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraazacyclopenta[e]azulen-6-yl]acetic acid methyl ester

Guidance literature:: methyl (S)-{4-(2'-formylbiphenyl-4-yl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate; With hydroxylamine hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 24h;

With 2-chloro-1,3-dimethylimidazolinium tetrafluoroborate; triethylamine; In dichloromethane; at 20 ℃; for 3h;

With water; In dichloromethane;