tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

Base Information

Chemical Name:tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate
CAS No.:1350550-44-5
Molecular Formula:C₂₅H₃₄N₆O₂
Molecular Weight:450.584
Hs Code.:

Synonyms:tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

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Chemical Property of tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

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Technology Process of tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

There total 10 articles about tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1350550-42-3
tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

: 5720-05-8
4-methylphenylboronic acid

: 1350550-44-5
tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 150 ℃; for 0.166667h; microwave irradiation;

Reference yield:

: 100047-42-5
6-(methylsulfanyl)-1H,2H,3H-pyrazolo[3,4-d]pyrimidin-3-one

: 1350550-44-5
tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus(V) oxybromide / acetonitrile / 16.5 h / 100 °C / pressure vessel; Sonographic reaction

1.2: 1 h / 0 °C

2.1: potassium carbonate / dimethyl sulfoxide / 0.33 h

2.2: 0.17 h / 150 °C / microwave irradiation

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

3.3: 2 h / 60 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 150 °C / microwave irradiation

With potassium phosphate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; phosphorus(V) oxybromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1306829-95-7
3-bromo-6-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1350550-44-5
tert-butyl 4-((6-(methylamino)-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.33 h

1.2: 0.17 h / 150 °C / microwave irradiation

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2.3: 2 h / 60 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 150 °C / microwave irradiation

With potassium phosphate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;