tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

Base Information

Chemical Name:tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate
CAS No.:1350550-42-3
Molecular Formula:C₁₈H₂₇BrN₆O₂
Molecular Weight:439.355
Hs Code.:

Synonyms:tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

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Chemical Property of tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

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Technology Process of tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

There total 10 articles about tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1350550-40-1
tert-butyl 4-((3-bromo-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

: 74-89-5
methylamine

: 1350550-42-3
tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

Guidance literature:: tert-butyl 4-((3-bromo-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In dichloromethane; ethyl acetate;

methylamine; In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield: 76.0%

: tert-butyl trans-4-((6-(methylthio)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

: 74-89-5
methylamine

: 1350550-42-3
tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

Guidance literature:: tert-butyl trans-4-((6-(methylthio)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In dichloromethane; water;

methylamine; In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield:

: 1306829-95-7
3-bromo-6-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1350550-42-3
tert-butyl 4-((3-bromo-6-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.33 h

1.2: 0.17 h / 150 °C / microwave irradiation

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2.3: 2 h / 60 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide;