(S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

• Chemical Name: (S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS No.: 928342-24-9
• Molecular Formula: C₃₁H₂₈N₂O₅S
• Molecular Weight: 540.64

Synonyms:(S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property of (S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

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Technology Process of (S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 2 articles about (S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-Fmoc L-Phe (35661-40-6) + Tosyl isocyanate (4083-64-1) → (S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate (928342-24-9)

Guidance literature:

DOI:10.1016/j.tetlet.2006.11.143

Reference yield: 70.0%

4-toluenesulfonyl azide (941-55-9) + N-Fmoc L-Phe (35661-40-6) → (S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate (928342-24-9)

Guidance literature:

With sodium hydride; chloro-diphenylphosphine; In chlorobenzene; at 20 - 80 ℃; for 14h; chemoselective reaction;

DOI:10.1002/chem.201201773

Reference yield: 95.0%

(S)-(9H-fluoren-9-yl)methyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate (928342-24-9) + trimethoxonium tetrafluoroborate (420-37-1) → {1-benzyl-2-[methyl-(toluene-4-sulfonyl)-amino]-2-oxo-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (928342-26-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2006.11.143

upstream raw materials:

N-Fmoc L-Phe

Tosyl isocyanate

4-toluenesulfonyl azide

Downstream raw materials:

{1-benzyl-2-[methyl-(toluene-4-sulfonyl)-amino]-2-oxo-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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