2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate

Base Information

• Chemical Name: 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate
• CAS No.: 140373-23-5
• Molecular Formula: C₁₄H₂₀N₂O₇S
• Molecular Weight: 360.388
• Mol file: 140373-23-5.mol

Synonyms:2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate

Chemical Property of 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate

There total 4 articles about 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (2-hydroxy-1-(3-nitrophenyl)ethyl)carbamate + methanesulfonyl chloride (124-63-0) → 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate (140373-23-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

d-α-amino-m-nitrophenylacetic acid (30077-08-8) → 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate (140373-23-5)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / methanol / Inert atmosphere; Cooling with ice; Reflux

2: triethylamine; sodium hydrogencarbonate / dichloromethane / 20 °C

3: tetrahydrofuran / 20 °C / Cooling with ice

4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With thionyl chloride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

methyl 2-amino-2-(3-nitrophenyl)acetate (687631-80-7,76604-97-2) → 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate (140373-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; sodium hydrogencarbonate / dichloromethane / 20 °C

2: tetrahydrofuran / 20 °C / Cooling with ice

3: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

methanesulfonyl chloride

d-α-amino-m-nitrophenylacetic acid

methyl 2-amino-2-(3-nitrophenyl)acetate

methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate

Downstream raw materials:

tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-(3-nitrophenyl)ethyl)carbamate

tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

ethyl 4-((3-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1 H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenyl)amino)butanoate

ethyl 4-((3-(1-amino-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenyl)amino)butanoate