2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine

Base Information

Chemical Name:2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine
CAS No.:1384840-58-7
Molecular Formula:C₅₈H₃₇Br₂N₅O
Molecular Weight:979.773
Hs Code.:

Synonyms:2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine

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Chemical Property of 2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine

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Technology Process of 2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine

There total 7 articles about 2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1384840-57-6
4,5-dibromo-9-methyl-1,8-diazaanthracene

: 1384840-59-8
2,12-diethynyl-7-(4'-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo-[c,h]acridine

: 1384840-58-7
2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In 1,4-dioxane; at 84 ℃; for 48h;
DOI:10.1021/ja3038905

Reference yield:

: 87330-35-6
1,4,6,9-tetrahydro-10-methylpyrido<3,2-g>quinoline-4,6-dione

: 1384840-58-7
2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / 1,4-dioxane / 48 h / 84 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; phosphorus tribromide; diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/ja3038905

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1384840-58-7
2,12-bis(4'-ethynyl-5'-bromo-9'-methyl-1',8'-diazaanthracene)-7-(4''-methoxyphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / ethylene glycol / 180 °C / Microwave irradiation

2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 20 h / 90 °C

3: potassium hydroxide / methanol; chloroform / 20 °C

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / 1,4-dioxane / 48 h / 84 °C

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonium acetate; diisopropylamine; potassium hydroxide; In 1,4-dioxane; methanol; chloroform; ethylene glycol; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1021/ja3038905