2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole

Base Information

Chemical Name:2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole
CAS No.:1198777-66-0
Molecular Formula:C₁₈H₁₇Cl₂NO₃S
Molecular Weight:398.31
Hs Code.:

Synonyms:2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole

Suppliers and Price of 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole

There total 5 articles about 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1198777-63-7
N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide

: 1198777-66-0
2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole

Guidance literature:: With silver(I) acetate;
DOI:10.1002/anie.200903743

Reference yield:

: 1198777-56-8
N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide

: 1198777-66-0
2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium / diethyl ether / 15 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: silver(I) acetate / dichloromethane / 48 h / 20 °C / Inert atmosphere; Reflux

With tetrabutyl ammonium fluoride; silver(I) acetate; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/ejoc.201402177

Reference yield:

: 90-60-8
3,5-dichlorosalicyclaldehyde

: 1198777-66-0
2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C / Inert atmosphere

2: tetraethoxy orthosilicate / 6 h / 160 °C / Inert atmosphere

3: magnesium / diethyl ether / 15 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

5: silver(I) acetate / dichloromethane / 48 h / 20 °C / Inert atmosphere; Reflux

With tetraethoxy orthosilicate; tetrabutyl ammonium fluoride; silver(I) acetate; potassium carbonate; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201402177