N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide

Base Information

Chemical Name:N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide
CAS No.:1198777-63-7
Molecular Formula:C₁₈H₁₇Cl₂NO₃S
Molecular Weight:398.31
Hs Code.:

Synonyms:N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide

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Technology Process of N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide

There total 4 articles about N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1198777-59-1
N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide

: 1198777-63-7
N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/anie.200903743

Reference yield:

: 1198777-56-8
N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide

: 1198777-63-7
N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium / diethyl ether / 15 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; magnesium; In tetrahydrofuran; diethyl ether;
DOI:10.1002/ejoc.201402177

Reference yield:

: 90-60-8
3,5-dichlorosalicyclaldehyde

: 1198777-63-7
N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C / Inert atmosphere

2: tetraethoxy orthosilicate / 6 h / 160 °C / Inert atmosphere

3: magnesium / diethyl ether / 15 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With tetraethoxy orthosilicate; tetrabutyl ammonium fluoride; potassium carbonate; magnesium; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201402177