N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide
CAS No.:1198777-59-1
Molecular Formula:C₂₁H₂₅Cl₂NO₃SSi
Molecular Weight:470.492
Hs Code.:

Synonyms:N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide

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Technology Process of N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide

There total 4 articles about N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1198777-56-8
N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide

: 78012-45-0
[3-(trimethylsilyl)prop-2-yn-1-yl]magnesium bromide

: 1198777-59-1
N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1002/anie.200903743

Reference yield: 27.0%

: 1198777-56-8
N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide

: 38002-45-8
3-bromo-1-(trimethylsilyl)-1-propyne

: 1198777-59-1
N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide

: N-[1-(3,5-dichloro-2-methoxyphenyl)-2-(trimethylsilyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide

Guidance literature:: 3-bromo-1-(trimethylsilyl)-1-propyne; With magnesium; In diethyl ether; at 20 ℃; for 15h;

N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide; In diethyl ether; dichloromethane;
DOI:10.1002/ejoc.201402177

Reference yield:

: 90-60-8
3,5-dichlorosalicyclaldehyde

: 1198777-59-1
N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C / Inert atmosphere

2: tetraethoxy orthosilicate / 6 h / 160 °C / Inert atmosphere

3: magnesium / diethyl ether / 15 h / 20 °C

With tetraethoxy orthosilicate; potassium carbonate; magnesium; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201402177