{4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone

Base Information

Chemical Name:{4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone
CAS No.:1443011-76-4
Molecular Formula:C₁₉H₂₁N₅O₂S₂
Molecular Weight:415.54
Hs Code.:

Synonyms:{4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone

Suppliers and Price of {4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone

There total 3 articles about {4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 10200-59-6
Thiazole-2-carbaldehyde

: 1443011-82-2
C₁₁H₁₅N₃O₂

: 1443011-76-4
{4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone

Guidance literature:: With sodium cyanoborohydride; zinc(II) chloride; In methanol; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.04.036

Reference yield:

: 1019-52-9
4-hydroxy-3,5-dinitrobenzoic acid

: 1443011-76-4
{4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; diisopropyl-carbodiimide; triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C

2: tin(II) chloride dihdyrate / ethanol / 0.5 h / 80 °C

3: sodium cyanoborohydride; zinc(II) chloride / methanol / 1.5 h / 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; sodium cyanoborohydride; benzotriazol-1-ol; triethylamine; zinc(II) chloride; diisopropyl-carbodiimide; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.036

Reference yield:

: 1443011-79-7
(4-hydroxy-3,5-dinitrophenyl)(pyrrolidin-1-yl)methanone

: 1443011-76-4
{4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethanol / 0.5 h / 80 °C

2: sodium cyanoborohydride; zinc(II) chloride / methanol / 1.5 h / 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; sodium cyanoborohydride; zinc(II) chloride; In methanol; ethanol;
DOI:10.1016/j.bmc.2013.04.036