(2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid

Base Information

Chemical Name:(2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid
CAS No.:1268809-47-7
Molecular Formula:C₂₇H₂₇NO₅Se
Molecular Weight:524.475
Hs Code.:

Synonyms:(2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid

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Chemical Property of (2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid

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Technology Process of (2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid

There total 8 articles about (2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1268809-46-6
prop-2-en-1-yl (2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoate

: 1268809-47-7
(2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 1.25h; Inert atmosphere;
DOI:10.1002/hlca.201000409

Reference yield:

: 1268809-45-5
prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate

: 1268809-47-7
(2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; N,N-dimethyl-formamide; acetone / 4 h / 0 °C / Inert atmosphere

2: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/hlca.201000409

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1268809-47-7
(2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: selenium

2: hypophosphorous acid / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

3: sodium hydroxide / water; N,N-dimethyl-formamide; acetone / 4 h / 0 °C / Inert atmosphere

4: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

With morpholine; selenium; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hypophosphorous acid; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/hlca.201000409