prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate

Base Information

• Chemical Name: prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate
• CAS No.: 1268809-45-5
• Molecular Formula: C₂₉H₂₉NO₇S
• Molecular Weight: 535.618
• Mol file: 1268809-45-5.mol

Synonyms:

Chemical Property of prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate

There total 3 articles about prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-(hydroxymethyl)propanoate (1268809-44-4) + p-toluenesulfonyl chloride (98-59-9) → prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate (1268809-45-5)

Guidance literature:

With pyridine; at 0 ℃; for 12h; Inert atmosphere;

DOI:10.1002/hlca.201000409

Reference yield:

prop-2-en-1-yl (2R)-3-(1,1-dimethylethoxy)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]propanoate (1268809-43-3) → prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate (1268809-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylsilyl iodide / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: pyridine / 12 h / 0 °C / Inert atmosphere

With pyridine; trimethylsilyl iodide; In dichloromethane;

DOI:10.1002/hlca.201000409

Reference yield:

(2R)-3-(1,1-dimethylethoxy)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]propanoic acid (847153-42-8) → prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propanoate (1268809-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Aliquat 336; sodium hydrogencarbonate / dichloromethane; water / 72 h / 20 °C

2: trimethylsilyl iodide / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: pyridine / 12 h / 0 °C / Inert atmosphere

With pyridine; trimethylsilyl iodide; Aliquat 336; sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1002/hlca.201000409

upstream raw materials:

prop-2-en-1-yl (2R)-3-(1,1-dimethylethoxy)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]propanoate

prop-2-en-1-yl (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-(hydroxymethyl)propanoate

p-toluenesulfonyl chloride

(2R)-3-(1,1-dimethylethoxy)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]propanoic acid

Downstream raw materials:

(2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoic acid

prop-2-en-1-yl (2S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(4-methoxyphenyl)methyl]selanyl}methyl)propanoate