2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester

Base Information

• Chemical Name: 2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester
• CAS No.: 220030-60-4
• Molecular Formula: C₉H₉F₂N₃O₄
• Molecular Weight: 261.185
• Mol file: 220030-60-4.mol

Synonyms:2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester

Chemical Property of 2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester

There total 1 articles about 2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,5-trifluoro-2-nitrobenzene (315-14-0) + chloroformic acid ethyl ester (541-41-3) → 2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester (220030-60-4) + 2-(3,5-difluoro-2-nitrophenyl)hydrazinecarboxylate ethyl ester

Guidance literature:

With pyridine; hydrazine; Yield given; Multistep reaction. Yields of byproduct given; 1) acetonitrile, 10 min;

DOI:10.1021/jo981095e

Reference yield:

2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester (220030-60-4) → N'-(4-amino-3,5-difluoro-phenyl)-hydrazinecarboxylic acid ethyl ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jo981095e

Reference yield:

2-(3,5-difluoro-4-nitrophenyl)hydrazinecarboxylate ethyl ester (220030-60-4) → 4-azido-3,5-difluorophenyldiazenecarboxylate, ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / acetic acid

2: aq. NaNO₂, aq. NaN₃ / aq. acetic acid / Ambient temperature

With sodium azide; hydrogen; sodium nitrite; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jo981095e

upstream raw materials:

1,3,5-trifluoro-2-nitrobenzene

chloroformic acid ethyl ester