N⁶-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine

Base Information

• Chemical Name: N⁶-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine
• CAS No.: 863871-03-8
• Molecular Formula: C₃₈H₄₁N₅O₇Si
• Molecular Weight: 707.858

Synonyms:N⁶-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine

Chemical Property of N⁶-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine

Chemical Property:

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Technology Process of N⁶-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine

There total 3 articles about N⁶-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N6-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine (863871-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dimethylformamide / 24 h / 20 °C

2: 2.05 g / pyridine / 16 h / 100 °C

With pyridine; In N,N-dimethyl-formamide;

DOI:10.1021/jm049029u

Reference yield:

2'-C-methyladenosine (15397-12-3) → N6-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine (863871-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dimethylformamide / 24 h / 20 °C

2: 2.05 g / pyridine / 16 h / 100 °C

With pyridine; In N,N-dimethyl-formamide;

DOI:10.1021/jm049029u

Reference yield:

5'-O-(tert-butyldimethylsilyl)-2'-C-methyladenosine + benzoic acid anhydride (93-97-0) → N6-dibenzoyl-9H-(3'-O-benzoyl-5'-O-tert-butyldimethylsilyl-2'-C-methyl-β-D-ribofuranosyl)adenine (863871-03-8)

Guidance literature:

With pyridine; at 100 ℃; for 16h;

DOI:10.1021/jm049029u

upstream raw materials:

benzoic acid anhydride

tert-butyldimethylsilyl chloride

2'-C-methyladenosine

Downstream raw materials:

N⁶-benzoyl-9-[3'-O-benzoyl-5',6'-dideoxy-6'-(diphenoxyphosphinyl)-2'-C-methyl-β-D-ribohexofuranosyl]adenine

N⁶-dibenzoyl-9H-(3'-O-benzoyl-2'-C-methyl-β-D-ribofuranosyl)adenine

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