(S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one

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Chemical Name:(S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one
CAS No.:1338327-07-3
Molecular Formula:C₂₃H₃₇BClNO₄Si
Molecular Weight:465.901
Hs Code.:

Synonyms:(S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one

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Chemical Property of (S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one

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Technology Process of (S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one

There total 5 articles about (S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.61%

: 1338327-08-4
(S)-1-(4-bromo-3-chlorobenzyl)-3-(tert-butyldimethylsilyloxy)pyrrolidin-2-one

: 73183-34-3
bis(pinacol)diborane

: 1338327-07-3
(S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; at 20 - 130 ℃; for 5h; Microwave irradiation;

Reference yield:

: 130403-91-7
(3S)-3-[tert-butyl(dimethyl)silyl]oxypyrrolidin-2-one

: 1338327-07-3
(S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 18 - 25 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 5 h / 20 - 130 °C / Microwave irradiation

With potassium acetate; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1338327-07-3
(S)-3-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1H-imidazole / dichloromethane / 16 h / 18 - 25 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 18 - 25 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 5 h / 20 - 130 °C / Microwave irradiation

With 1H-imidazole; dmap; potassium acetate; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; N,N-dimethyl-formamide;